OVERVIEW
VARIANTS
OVERVIEW
VARIANTS
HEALTH BENEFITS
Anti-Stress
Anti-inflammatory
Anti-aging
Benefits of reduced cortisol levels
USP
USP
SCIENCE
Efficacy
Efficacy
Pre-Clinical Study 1: Effect of Serocen on serum cortisol levels in rats with isolation induced depression.
Result: Serocen significantly reduce serum cortisol levels in rats with isolation induced depression.
SCIENCE
Scenario
Scenario
- According to research, around 30% of overweight men have Testosterone Deficiency.
- 38% of men above 40 have testosterone levels below 300 ng/dl.
- Above the 80-year threshold, more than 50% of men have testosterone levels below 300 ng/dl.
- As far as diabetes patients go, up to 24% of men have low testosterone levels.
- Low T-levels are harmful for all aspects, including physical, mental, and social
Reference:
Foundation
Foundation
A broad spectrum of systematic reviews and scientific data demonstrated that fenugreek and its extracts improve glycemic and lipid profiles. Fenugreek is known to have antioxidant, anti-carcinogenic, gastro protective, anti-inflammatory, antimicrobial, immunological, anti-obesity, and hepatoprotective effects, and are beneficial to women’s health. Further, previous studies reported that fenugreek improved cognitive functions and Parkinson’s symptoms and showed anti anxiety, antidepressant, and neuroprotective properties. A recent study has reported the beneficial effects of fenugreek and its extract on hormonal-related statuses, such as galactagogue in lactating women and male impotence.
The presence of fenugreek seeds in various traditional medicinal systems is due to their composition of diverse phytochemicals, including Glycosides.
Potential benefits of fenugreek glycosides in testosterone production include: Increased Testosterone Levels:
- Fenugreek supplementation may lead to an increase in testosterone levels, which could have positive effects on muscle mass, strength, and overall vitality.
- Enhanced Libido: Fenugreek has been traditionally used as an aphrodisiac, and its potential influence on testosterone levels may contribute to improvements in libido and sexual health.
- Improved Exercise Performance: Higher testosterone levels may be associated with increased exercise performance and muscle strength, making fenugreek an area of interest for athletes and those involved in physical fitness.
- Spermatogenesis Support: Testosterone plays a crucial role in spermatogenesis (sperm production), and fenugreek’s potential impact on testosterone levels may have implications for male reproductive health.
Mechanism of action
Mechanism of Action
Testosurge® is standardized to include a specific combination of steroidal and flavonoid glycosides. The steroidal glycosides in Testosurge® enhance the effectiveness of testosterone by competitively binding with SHBG. When testosterone is released into the bloodstream approximately 60-70% of it binds to SHBG. The steroidal glycosides from Testosurge® binds to SHBG and make testosterone free and bioavailable.
On the other hand, the flavonoid glycosides in Testosurge® play a role in increasing testosterone production. They achieve this by enhancing the expression of the steroidogenic acute regulatory (StAR) protein in Leydig cells. Testosterone is produced within the mitochondria of Leydig cells through steroidogenesis, where the StAR protein facilitates the entry of cholesterol into the mitochondrion.
Testosurge® has demonstrated inhibitory activity against5-alpha reductase and aromatase in cell line studies. 5-alpha reductase is an enzyme responsible for converting testosterone into DHT, while aromatase converts testosterone into Estrogen. This inhibition activity suggests that Testosurge® may help regulate the levels of these hormones in the body.
Additionally, Testosurge® can inhibit PDE5 enzyme which canresult in improved vasodilation and penile blood flow.
Efficacy
Efficacy
Human Clinical Study 1: Effects of Testosurge® supplementation on strength, body composition and hormonal profiles during an 8-week resistance training program.
Result: 500 mg of daily Testosurge®supplementation significantly impacted Body Fat Percentage, Total Testosterone and Bioavailable Testosterone.
Human Clinical Study 2: Effects of Single dose Testosurge® on serum testosterone levels of healthy sedentary male subjects
Result: Single dose of Testosurge® significantly increased Free Testosterone, Bioavailable Testosterone, and Total Testosterone Levels after 10 hours of administration.
Scenario
Scenario
- Anxiety disorders are the world’s most common mental disorders, affecting 301 million people in 2019.
- More women are affected by anxiety disorders than men.
- Research shows that mental illnesses are common in the United States, affecting tens of millions of people each year. Estimates suggest that only half of people with mental illnesses receive treatment.
- 55% of Americans are stressed during the day. The global average of the number of stressed people out of 143 countries is 35%.
Reference:
FOUNDATION
FOUNDATION
Centella asiatica (CA), a clonal, perennial herbaceous creeper belonging to the family Umbellifere (Apiceae) is found throughout India growing in moist places up to an altitude of 1800 m. It is found in most tropical and subtropical countries growing in swampy areas, including parts of India, Pakistan, Sri Lanka, Madagascar, and South Africa and South pacific and Eastern Europe.
In Ayurveda, CA is one of the main herbs for revitalizing the nerves and brain cells. Eastern healers relied on CA to treat emotional disorders, such as depression, that were thought to be rooted in physical problems.
The primary active constituents of CA are saponins (also called triterpenoids), which include Asiaticoside and madecassoside.
Centella asiatica is reputed for its beneficial effects in various neurological disorders.
The synergistic effect of Asiaticoside & Madecassosides can significantly reduce serum cortisol levels & generalized anxiety disorders.
Mechanism
of action
Mechanism of Action
Stress, is an undeniable reality of modern life, affecting millions worldwide. It is the body’s natural response to perceived threats or challenges. When faced with a stressful situation, the body activates its “fight or flight” response, releasing hormones such as adrenaline and cortisol to prepare for action. While this response can be beneficial in short bursts, chronic stress – the persistent activation of this response over time – can have detrimental effects on health and well-being. Chronic stress causes disruption in daily life, affecting productivity, mood, and overall well-being.
Chronic Stress is often the precursor to conditions such as Depression, Anxiety which are primary causes for Mood disorders, Productivity loss, Loss of appetite, and in extreme cases Suicidal thoughts. In the current situation various Anti-depressant medications are easily available over OTC and are consumed without regulation by masses. The delayed onset of action of these antidepressant drug necessitates dosage increase to effectively address changes in depressive symptoms. Increased dosages and long-term consumption of these OTCs have various side effects.
Centella Asiatica commonly known as Gotu Kola, Indian Pennywort has been used in Indian ayurvedic system as a” Brain Food” because of its richness in Neuroactive properties from compounds such as Triterpenoids, saponins including Asiaticoside, madecassoside, Asiatic acid, madeccasic acid, oxyasiaticoside, centelloside, Brahmoside, and many others. These marker compounds have a well-researched therapeutic property to improve mood disorders, reduce oxidative stress, and reduce inflammation.
Serocen is standardized to triterpenoids derived from Centella Asiatica leaves. Extract contains a potent composition of total triterpenoids NLT 50% with a unique combination of Asiaticoside and madecassoside to give a synergistic effect on reducing the symptoms of depression, anxiety, and mood disorders. It also reduces various side effects of present-day medications through the following mechanism of action:
5HT-1a Blocker: Total terpenoids rich in asiaticoside and madecassoside, promote the increase of Serotonin (5HT) in blood flow, a hormone responsible for mood elevation and reducing the stress related Cortisol Hormone.
Serocen works with a unique set of mechanism where it blocks the 5HT-1a receptors, responsible for reuptake of serotonin released from presynaptic neuron in the synaptic cleft.
The increased Serotonin attaches itself to the receptors present in post synaptic neuron to reduce the condition of depression, and promotes mood elevation.
It is also suggested to that other factors which can increase the serotonin production in body such as:
- Physical exercise
- Tryptophan rich diets
- Bright sunlight
Efficacy
Efficacy
Pre-Clinical Study 1: Effect of Serocen on serum cortisol levels in rats with isolation induced depression.
Result: Serocen significantly reduce serum cortisol levels in rats with isolation induced depression.
Certification
Certification