OVERVIEW
VARIANTS
OVERVIEW
VARIANTS
HEALTH BENEFITS
Benefits of healthy skin care routine
USP
USP
SCIENCE
Scenario
Scenario
- According to research, around 30% of overweight men have Testosterone Deficiency.
- 38% of men above 40 have testosterone levels below 300 ng/dl.
- Above the 80-year threshold, more than 50% of men have testosterone levels below 300 ng/dl.
- As far as diabetes patients go, up to 24% of men have low testosterone levels.
- Low T-levels are harmful for all aspects, including physical, mental, and social
Reference:
Foundation
Foundation
A broad spectrum of systematic reviews and scientific data demonstrated that fenugreek and its extracts improve glycemic and lipid profiles. Fenugreek is known to have antioxidant, anti-carcinogenic, gastro protective, anti-inflammatory, antimicrobial, immunological, anti-obesity, and hepatoprotective effects, and are beneficial to women’s health. Further, previous studies reported that fenugreek improved cognitive functions and Parkinson’s symptoms and showed anti anxiety, antidepressant, and neuroprotective properties. A recent study has reported the beneficial effects of fenugreek and its extract on hormonal-related statuses, such as galactagogue in lactating women and male impotence.
The presence of fenugreek seeds in various traditional medicinal systems is due to their composition of diverse phytochemicals, including Glycosides.
Potential benefits of fenugreek glycosides in testosterone production include: Increased Testosterone Levels:
- Fenugreek supplementation may lead to an increase in testosterone levels, which could have positive effects on muscle mass, strength, and overall vitality.
- Enhanced Libido: Fenugreek has been traditionally used as an aphrodisiac, and its potential influence on testosterone levels may contribute to improvements in libido and sexual health.
- Improved Exercise Performance: Higher testosterone levels may be associated with increased exercise performance and muscle strength, making fenugreek an area of interest for athletes and those involved in physical fitness.
- Spermatogenesis Support: Testosterone plays a crucial role in spermatogenesis (sperm production), and fenugreek’s potential impact on testosterone levels may have implications for male reproductive health.
Mechanism of action
Mechanism of Action
Testosurge® is standardized to include a specific combination of steroidal and flavonoid glycosides. The steroidal glycosides in Testosurge® enhance the effectiveness of testosterone by competitively binding with SHBG. When testosterone is released into the bloodstream approximately 60-70% of it binds to SHBG. The steroidal glycosides from Testosurge® binds to SHBG and make testosterone free and bioavailable.
On the other hand, the flavonoid glycosides in Testosurge® play a role in increasing testosterone production. They achieve this by enhancing the expression of the steroidogenic acute regulatory (StAR) protein in Leydig cells. Testosterone is produced within the mitochondria of Leydig cells through steroidogenesis, where the StAR protein facilitates the entry of cholesterol into the mitochondrion.
Testosurge® has demonstrated inhibitory activity against5-alpha reductase and aromatase in cell line studies. 5-alpha reductase is an enzyme responsible for converting testosterone into DHT, while aromatase converts testosterone into Estrogen. This inhibition activity suggests that Testosurge® may help regulate the levels of these hormones in the body.
Additionally, Testosurge® can inhibit PDE5 enzyme which canresult in improved vasodilation and penile blood flow.
Efficacy
Efficacy
Human Clinical Study 1: Effects of Testosurge® supplementation on strength, body composition and hormonal profiles during an 8-week resistance training program.
Human Clinical Study 2: Effects of Single dose Testosurge® on serum testosterone levels of healthy sedentary male subjects
Scenario
Scenario
The global skin care products market size was estimated at USD 135.83 billion in 2022 and is projected to grow at a compound annual growth rate (CAGR) of 4.7% from 2023 to 2030.
A recent study reported by the Environmental Working Group found that the average adult used nine cosmetic products daily. More than 25% of women used 15 or more. It can be safely assumed that most of these products contain preservatives.
In a survey on adverse effects of synthetic cosmetics 500 participants faced the following:
- Allergic reactions 55.7%
- Redness of skin 43.3%
- Eye irritation 33.6%
- Watering in the Eyes 32%
- Blackish discoloration of skin 26.5%
- Headache 15.7%
Reference:
- https://www.grandviewresearch.com/industry-analysis/skin-care-products-market#:~:text=The%20global%20skin%20care%20products,to%20positively%20impact%20the%20growth.
- https://europepmc.org/article/med/15785137
- https://www.researchgate.net/publication/375156388_A_survey_study_on_adverse_effects_of_synthetic_cosmetics#:~:text=Results%3A%20Among%20500%20inmates%20of,harmful%20ingredients%20used%20in%20cosmetics.
FOUNDATION
FOUNDATION
Originating in the Mediterranean, southern Europe, and western Asia, fenugreek is a highly esteemed herb in traditional systems for its diverse benefits. The seeds, renowned for their multifaceted advantages, not only enhance culinary experiences with their distinctive flavour but also play a crucial role in promoting health.
With a rich history in traditional medicinal practices like Ayurveda and traditional Chinese medicine, fenugreek is valued for supporting digestion, maintaining heart health, and regulating blood sugar levels. Its enduring reputation across cultures highlights its versatility and health-promoting properties.
Fenugreek seeds contain a significant amount of complex Eleutheroside-C & Oligosaccharides, which work together synergistically to enhance skin radiance by reducing wrinkles and promoting skin barrier health.
Mechanism
of action
Mechanism of Action
Skin is the largest organ in the human body and serves as a protective shield of body against the heat, light, injury, infections etc.
The harsh environmental conditions co-factored with various lifestyle behaviours such as smoking, Drinking Alcohol, Unhealthy diet, Physical inactivity, Stress can cause skin problems such as Skin Inflmmation, Collagen Degradation etc. which coherently leads to Increased Biological aging of Skin.
Aging of the skin can be prevented by carrying out various lifestyle changes and using Anti-aging treatments such as Creams, Topical Solutions etc. to prevent the skin damage caused from various endogenous and exogenous conditions.
Anti-aging creams have become a billion-dollar industry claiming to reverse or reduce the biological aging of skin. Most of the anti-aging creams present in market are made using ingredients derived from harsh chemicals which causes Skin irritation, Skin Infections, Skin sensitization and in severe cases it may raise the risk of cancer.
FenuSmooth is a dual action complex derived from naturally available Fenugreek seed. The complex is forged to display the Synergistic effect of Adaptogens standardized to Eleutheroside-C and Oligosaccharide anti-ageing property.
FenuSmooth complex shows its dual action on ageing, and improves the skin health through the following mechanism of action:
- Anti-Wrinkle Action: Reactive oxygen Species (ROS), generated from the various unfavourable skin conditions tend to increase the metalloproteinase in the Fibroblast. This metalloproteinase increases collagen degradation thus increasing the biological aging of the skin. Eleutheroside-C complex downregulates the metalloproteinase enzyme to reduce collagen degradation and prevent wrinkle formation.
- Improves Skin Barrier Function: Tight Junction proteins, found in the Epidermis layer main function is to hold the epidermal cells tightly and prevent the loss of essential fluids required for keeping skintight (Wrinkle Free) and under hydrated condition. This Tight junction protein loosens up as the skin ages and wrinkles are formed. Wrinkles also act as a site of various skin related problems due to increased access for deposition of harmful elements. Eleutheroside-C Complex upregulates the action of tight junction protein and maintains the hydration of skin by improving skin barrier function and coherently showing anti-aging effects.
Efficacy
Efficacy
Human Clinical Study 1: Wrinkle Reduction & Skin Moisturization Study
Results: Fenusmooth showed significant reduction in wrinkle by 25% & improves skin hydration.