OVERVIEW
VARIANTS
OVERVIEW
VARIANTS
HEALTH BENEFITS
Helps manage hypertension
Promotes better blood circulation
Improves chronic hyperuricemia condition
Anti-inflammatory
Supports better diuretic function
Benefits of reduced cortisol levels
USP
USP
Scenario
Scenario
- Hypertension is a critical health problem and worse other cardiovascular diseases. It is mainly of two types: Primary or essential hypertension and Secondary hypertension. Hypertension is the primary possibility feature for coronary heart disease, stroke and renal vascular disease.
- Around 17 million deaths worldwide from cardiovascular disease occur each year, accounting for almost one third of all fatalities. Additionally, headaches from high blood pressure cause 9.4 million lives worldwide each year. At least 45% of fatalities from coronary heart disease and 51% of deaths from stroke are attributable to hypertension.
- According to a 2008 international survey, approximately 40% of adults aged 25 and older experienced excessive anxiety; the number of people worldwide increased from 600 million in 1980 to at least one billion in 2008. (Global status report on non- communicable diseases 2010 Geneva).
- Proper medication, lifestyle and nutritional adjustments can enhance blood pressure control and lessen the risk of associated health issues.
Reference:
https://www.mediresonline.org/article/hypertension-and-plant-extract-as-a-solution
FOUNDATION
FOUNDATION
Originating in the Mediterranean, southern Europe, and western Asia, Celery is a highly esteemed herb in traditional systems for its diverse benefits. The seeds, renowned for their multifaceted advantages, not only enhance culinary experiences with their distinctive aroma but also play a crucial role in promoting health.
With a rich history of traditional Ayurveda, Celery Seed is valued for supporting digestion, improving Gut Health, Supports Heart Health. Its enduring reputation across cultures highlights its versatility and health-promoting properties.
Celery seeds are rich in Phthalides and Flavonoids which are researched show anti-hypertensive effects by their vasodilatory pathways. The synergistic combination of Phthalides and Flavonoids also shows diuretic property which improves kidney function.
Mechanism
of action
Mechanism of Action
A Comprehensive Review on the Health Benefits of Celery Seed Extract: Highlighting the Importance of Phthalides (Standardized to 3-N Butyl Phthalide and Sedanolide)
Celery seed extract, derived from the seeds of Apium graveolens, has been used in traditional medicine for its numerous health benefits. It is rich in phytochemicals, such as flavonoids, coumarins, and volatile oils, which contribute to its therapeutic properties. Historically, celery seed has been employed to treat conditions like gout, arthritis, and various inflammatory disorders. Recently, it has gained attention for its potential cardiovascular and neuroprotective benefits, primarily due to the presence of bioactive compounds such as Phthalides including 3 n-butylphthalide (3nBP) & Sedanolide.
Benefits of Unique Bioactive Profile
Celery seed extract contains several bioactive compounds, the most notable being Phthalide including 3-n-Butylphthalide (3nB) & Sedanolide, which are believed to be responsible for its therapeutic effects. These compounds have been shown to exert significant antioxidant, anti-inflammatory, diuretic, neuroprotective, and bone health-promoting properties.
The identified bioactive profile of celery seed standardized to Phthalides (3-N Butylphthalide & Sedanolide) has been extensively studied and researched to improve the conditions of:
- Hypertension or High Blood Pressure: A common condition which can deteriorate the cardiovascular health by being a significant risk factor for fatal and non-fatal cardiovascular events. Studies have shown that proper blood circulation reduces the risk of Hypertension and its associated effects such as Stroke, myocardial infarction and other cardiovascular events.[1]
- Hyperuricemia: An arthritic condition which can reduce the quality of life due to the pain, swelling, redness at the affected joints. The condition of Hyperuricemia, or commonly called Gout, is observed when the body produces more Uric acid than normal range (normal range of uric acid is up to 7 mg/dl)[2] or when Uric acid is not excreted out properly through Kidney. Both conditions lead to the deposition of monosodium urate (MSU) crystals or gout stones at joints causing severe pain, inflammation and redness.
Reducing the production of Uric acid along with proper excretion of MSU can improve the condition of Gout. Also, lowering inflammatory markers in the joints and supporting proper kidney function, can additionally help in improving the condition of Gout.
Celery Seed Extract Standardized to Total primarily 3-N Butyl Phthalide and Sedanolide, can improve the quality of life by improving the condition of Hypertension and Joint Health.
Rationale for Celery seed Extract in Hypertension
The unique bioactive profile standardized to Total Phthalides including 3-NBP and sedanolide has been well studied in various Preclinical and Clinical Studies to understand its mechanistic approach and its therapeutic potential in treatment of Hypertension.
One such study discussed the vasodilatory effects of Celery Seed extract on endothelial tissues. A preclinical in-vitro and in-vivo study explains the vasorelaxation of endothelial cells by the following mechanism of action:
Inhibition of Calcium/Ca2+ channel: Vasoconstriction of the endothelial cells especially aortic smooth muscle cells becomes high when there is influx of extracellular Calcium/Ca2+ ions. Studies suggest Butyl Phthalides has the same mechanistic approach as calcium channel blockers thus reducing the Phosphorylation of Myosin heads of Smooth muscle cells. This reduced phosphorylation causes vasorelaxation. The calcium blockade property of Butyl Phthalides is assumed to be responsible for showing Hypotensive effects.[3]
Human Clinical Data: Improving the Systolic/Diastolic Blood Pressure
In 30 Mild to Moderate Hypertensive Patients, it was found that a standardized celery seed extract, rich in Phthalides including 3-N Butyl Phthalate has shown clinically relevant blood pressure-lowering effects. This study evaluated the potential of standardized Celery seed extract in showing the hypotensive property. After the 6 Week Study, it was found that there is a significant decrease in both systolic blood pressure (SBP) and diastolic blood pressure (DBP) compared to baseline.
The authors of the study concluded that significant reduction in SBP & DBP is due to vasodilatory property of 3-NBP mediated by its calcium channel inhibiting property. They further concluded that the findings of the study suggest celery seed extract can be potential
alternative to present day medications for hypertension as celery seed extract does not inhibit Angiotensin Converting Enzyme (ACE) which lowers the cerebral blood flow. [4]
Rationale for Celery Seed Extract in Hyperuricemia
Role of Flavonoids & Phthalides
Flavonoids and Phthalides constitute the major active compounds in celery seeds. These compounds have been extensively studied through various preclinical and clinical studies for their therapeutic potential. The studies suggest their anti-inflammatory property, diuretic property and antioxidant properties can be an alternative to various conventional medicines.
One such study highlights the potential of this unique composition of flavonoids and Phthalides as an alternative for improving the condition of Chronic Hyperuricemia. Studies suggest mechanistic pathways that a standardized celery seed extract follows to reduce chronic conditions of Hyperuricemia:
- Xanthine Oxidase Inhibitor: Purines from foods and body cells follow a pathway where the enzyme, xanthine oxidase, acts on intermediates hypoxanthine and xanthine to form uric acid. The bioactive of the celery seed extract acts as xanthine oxidase inhibitor and thus prevents the enzymatic action required for conversion of purines to uric acid.[1]A few research also indicates that flavonoids and phthalides in the celery seed extract show diuretic property which improves the excretion of uric acid in natural as well as crystal forms.[5]
References:
James M. Rippe, MD, Lifestyle Strategies for Risk Factor Reduction, Prevention, and Treatment of Cardiovascular Disease[1]
G Desideri : Is it time to revise the normal range of serum uric acid levels?[2]
- Tsi, Cardiovascular Pharmacology of 3-nbutylphthalidein Spontaneously Hypertensive Rats[3]
- Madhavi, A Pilot Study to Evaluate the Antihypertensive effect of a Celery Extract in Mild to Moderate Hypertensive Patients[4]
Halmin; Effect of celery extract (Apium gravolens linn) on uric acid reduction in elderly[5]
Certification
Certification
