OVERVIEW
VARIANTS
OVERVIEW
VARIANTS
HEALTH BENEFITS
Accelerates Nutrient Delivery
Improves exercise performance
Sensory affect – feel after the first dose
Benefits of better ejection fraction
USP
USP
SCIENCE
Scenario
Scenario
- According to research, around 30% of overweight men have Testosterone Deficiency.
- 38% of men above 40 have testosterone levels below 300 ng/dl.
- Above the 80-year threshold, more than 50% of men have testosterone levels below 300 ng/dl.
- As far as diabetes patients go, up to 24% of men have low testosterone levels.
- Low T-levels are harmful for all aspects, including physical, mental, and social
Reference:
Foundation
Foundation
A broad spectrum of systematic reviews and scientific data demonstrated that fenugreek and its extracts improve glycemic and lipid profiles. Fenugreek is known to have antioxidant, anti-carcinogenic, gastro protective, anti-inflammatory, antimicrobial, immunological, anti-obesity, and hepatoprotective effects, and are beneficial to women’s health. Further, previous studies reported that fenugreek improved cognitive functions and Parkinson’s symptoms and showed anti anxiety, antidepressant, and neuroprotective properties. A recent study has reported the beneficial effects of fenugreek and its extract on hormonal-related statuses, such as galactagogue in lactating women and male impotence.
The presence of fenugreek seeds in various traditional medicinal systems is due to their composition of diverse phytochemicals, including Glycosides.
Potential benefits of fenugreek glycosides in testosterone production include: Increased Testosterone Levels:
- Fenugreek supplementation may lead to an increase in testosterone levels, which could have positive effects on muscle mass, strength, and overall vitality.
- Enhanced Libido: Fenugreek has been traditionally used as an aphrodisiac, and its potential influence on testosterone levels may contribute to improvements in libido and sexual health.
- Improved Exercise Performance: Higher testosterone levels may be associated with increased exercise performance and muscle strength, making fenugreek an area of interest for athletes and those involved in physical fitness.
- Spermatogenesis Support: Testosterone plays a crucial role in spermatogenesis (sperm production), and fenugreek’s potential impact on testosterone levels may have implications for male reproductive health.
Mechanism of action
Mechanism of Action
Testosurge® is standardized to include a specific combination of steroidal and flavonoid glycosides. The steroidal glycosides in Testosurge® enhance the effectiveness of testosterone by competitively binding with SHBG. When testosterone is released into the bloodstream approximately 60-70% of it binds to SHBG. The steroidal glycosides from Testosurge® binds to SHBG and make testosterone free and bioavailable.
On the other hand, the flavonoid glycosides in Testosurge® play a role in increasing testosterone production. They achieve this by enhancing the expression of the steroidogenic acute regulatory (StAR) protein in Leydig cells. Testosterone is produced within the mitochondria of Leydig cells through steroidogenesis, where the StAR protein facilitates the entry of cholesterol into the mitochondrion.
Testosurge® has demonstrated inhibitory activity against5-alpha reductase and aromatase in cell line studies. 5-alpha reductase is an enzyme responsible for converting testosterone into DHT, while aromatase converts testosterone into Estrogen. This inhibition activity suggests that Testosurge® may help regulate the levels of these hormones in the body.
Additionally, Testosurge® can inhibit PDE5 enzyme which canresult in improved vasodilation and penile blood flow.
Efficacy
Efficacy
Human Clinical Study 1: Effects of Testosurge® supplementation on strength, body composition and hormonal profiles during an 8-week resistance training program.
Result: 500 mg of daily Testosurge®supplementation significantly impacted Body Fat Percentage, Total Testosterone and Bioavailable Testosterone.
Human Clinical Study 2: Effects of Single dose Testosurge® on serum testosterone levels of healthy sedentary male subjects
Result: Single dose of Testosurge® significantly increased Free Testosterone, Bioavailable Testosterone, and Total Testosterone Levels after 10 hours of administration.
Scenario
Scenario
- Cardiac output (CO) is the amount of blood pumped by the heart minute and is the mechanism whereby blood flows around the body, especially providing blood flow to the brain and other vital organs.
- The body’s demand for oxygen changes, such as during exercise, and the cardiac output is altered by modulating both heart rate and stroke volume.
- The pattern of blood flow changes dramatically when a person goes from resting to exercising. At rest, the skin and skeletal muscles receive about 20 percent of the cardiac output.
- During exercise, more blood is sent to the active skeletal muscles, and, as body temperature increases, more blood is sent to the skin. This process allows about 80 percent of the cardiac output to go to active skeletal muscles and skin at maximal rates of work.
Reference:
FOUNDATION
FOUNDATION
Originating in the Mediterranean, southern Europe, and western Asia, Fenugreek is a highly esteemed herb in traditional systems for its diverse benefits. The seeds, renowned for their multifaceted advantages, not only enhance culinary experiences with their distinctive flavour but also play a crucial role in promoting health.
With a rich history in traditional medicinal practices like Ayurveda and traditional Chinese medicine, fenugreek is valued for supporting digestion, maintaining heart health, and regulating blood sugar levels. Its enduring reputation across cultures highlights its versatility and health-promoting properties.
Fenugreek seeds contain a significant number of secondary metabolites such as Glycosides, Steroidal glycosides, flavonoids, etc. This group of secondary metabolites has been well researched and documented for various health benefits like anti inflammation, anti-diabetic, etc.
Mechanism
of action
Mechanism of Action
In recent times, a notable increase is seen in the cases of heart failures due to various heart diseases. This significant rise encompasses not just the elderly population with chronic heart conditions but surprisingly, young adults who show no signs of chronic illness.
The risk of heart failures associated with young adults with no signs of chronic illness is due to factors such as Obesity, Diabetes, Sedentary lifestyle, Calorie rich diet, atherosclerosis, and various others. A one common condition associated with every factor is reduction in the Ejection Fraction.
Ejection fraction (EF) is a vital measurement used to assess the pumping function of the heart, particularly the left ventricle. It represents the percentage of blood that is pumped out of the left ventricle with each heartbeat. A normal ejection fraction typically falls between 50% and 70%, but a reduced ejection fraction that falls less than 40% can be lead to heart failure or chronic heart ailment.
A normal Ejection fraction maintains the steady flow of oxygen in the body via the blood and improves the nutrient delivery required for the proper functioning of various organs in the body.
Hyperox is a standardized Glycosides marker compound extracted from Fenugreek Seeds. Extract contains a potent composition of Glycosides NLT 30% to synergistically elevate the ejection fraction percentage from a reduced level to a normal one through following mechanism of action:
- Improved Ejection Function: Glycosides combination of Fenugreek seed such as Vitexin, Iso-Vitexin, Vicenin-1 has been researched to improve the contractility and relaxation of cardiac muscle cells, thereby improving the heart’s pumping efficiency. Increased efficiency improves the Ejection Fraction percentage and reduces the risk of heart failure.
- Improved Nutrient supply: Glycosides combination of Fenugreek Seed improves the nutrient supply along with flow of oxygen via blood to the organs when there is Increased requirement of oxygen or vital nutrients for enhanced performance during running, highly intensive exercise.
- Antioxidant and Anti-inflammatory Properties: Oxidative stress and inflammation play pivotal roles in cardiovascular diseases. Fenugreek glycosides exhibit antioxidant and anti-inflammatory actions, which may protect cardiac tissues from damage and promote overall heart health.
Certification
Certification
